Background: Radiation is energy that travels through space or matter. Electromagnetic radiationrnwhich carries sufficient energy per photon to remove bound electrons from atomic shells isrncalled ionizing radiation. The relevance of imaging with ionizing radiation in medicine is widelyrnacknowledged due to the benefits of the imaging studies for clinical care of patients. It isrnimportant that the users of radiation are aware not only of the clinical benefits of medicalrnimaging but also of the short and long-term radiation risks. rnObjectives: The objective of this study is to assess knowledge, attitude and practice of medicalrnradiation workers towards radiation hazards and protection in Tikur Anbessa SpecializedrnHospital in Addis Ababa, Ethiopia from December 2020 to February 2021. rnMethod: A cross-sectional hospital-based study was carried out among medical radiationrnworkers in three departments (radiology, oncology and nuclear medicine) of TASH. The datarnwas collected by filling semi-structured questionnaires which are designed to assess KAP. SPSSrnVersion 25 software used for analysis, and using one way ANOVA, association of differentrnparameters was shown. rnResult: One hundred and five questionnaires were collected and analyzed. The age range ofrnrespondents was 24-50 (32.67Â±4.53), most of them were males 64(61%). Among thernrespondents, only 39(37.1%) had on-job trainings. The use of dosimeters is poor 35(33.3%).rnSeventy-nine (75.2%) of respondents believe the information that they have about radiation isrnsufficient. Among the respondents, 61(58.1%) showed unsatisfactory knowledge level ofrnradiation hazards and protection, 67(63.8%) showed inadequate practice of safety measures butrn92(87.6%) have good attitude towards radiation protection. Significant association between KAPrnof the respondents and age (p=0.026), educational level (p=0.014), work experience (p=0.005)rnand on-job trainings (p=0.004) were observed in this study. rnConclusion and recommendations: Despite of good attitude, this study demonstrated poorrnradiation protection practices and unsatisfactory results in knowledge assessment of thernparticipants towards radiation hazards and protection. Therefore, this study recommends periodicrnin-service training and regular monitoring of occupationally exposed health workers as well asrnuninterrupted supply of radiation protection tools.