Background:Early diagnosis and improved cancer treatments have increased the number ofrncancer survivors. Accordingly, cancer rehabilitation has been increasingly recognized as a keyrnfactor in the management of cancer survivors. In Ethiopia, the number of cancer cases increasesrnfrom year to year TikurAnbessa Specialized Hospital is the only hospital in the country thatrnrender a comprehensive cancer therapy receiving patients from all over the country. However,rnthe hospital has no cancer rehabilitation center. This overload can lead to inadequate care andrnalso decrease quality of life and survival rate of the cancer patients. Hence, this study was tornexplored the initiation of cancer rehabilitation service with its challenges and potentialrnopportunities from the health workers perspectives.rnMethods: qualitative study was conducted among health workers at TikurAnbessa SpecializedrnHospital, Addis Ababa, Ethiopia using the purposive sampling that includes_eighthealthrnworkers. Data were collected through in-depth interview. The data analysis was performedrnusingAtlas-ti soft wear version 7.5.16.rnResult:The result of the analysis led to established under the following threethemes and elevenrnsub-theme which are perspective of participant initiation cancer rehabilitation,Participantsrnperspective of challenges for Cancer Rehabilitation service and participants perspective ofrnexisting/potential opportunities for the initiation of cancer rehabilitation.in this study the healthrnworker perceived for initiation of cancer rehabilitation health policy, organizational ,healthrnprofessional, perceived patient and family related challenges and opportunities.A graphicrnrepresentation of the interaction was created for these categories and how they affect therninitiation of rehabilitation services for cancer patients.rnConclusion: findings of the study is that the government is not giving adequate attention forrncancer as a general and rehabilitation service in particular. This can be seen easily as it drafts anyrnpolicy or guide line and also did not allocate any budget. The other major finding is thatrninstitutional problems like workload, lack of working space and manpower.These findings canrninform the government and stakeholders should consider the vitality of rehabilitation servicernsince cancer is spreading dramatically