Clinocopathologic Features Treatment Pattern And Overall Survival Of Patients With Osteosarcoma Treated At Radiotherapy Center Of Tikur Anbessa Specialized Hospital Ethiopia Cross-sectional Study.

Background: Primary malignant tumors of bone are extremely rare neoplasms accounting forrn10).rnSTATA software version 16.0 was used for statistical analysis.rnResult: From 80 patients included in our study, the age ranged between 11 and 58 years with arnmedian age of 19.5 years. Ostoesarcoma peaks between 15-19 years of age. From all patients,rn93.75% came after 3 months of the onset of symptoms. Thirty-four patients (42.5%) hadrndocumented distant metastasis at presentation. Of all patients with extremity tumors that hadrnsurgery, 43 patients (95.5%) had an amputation. Seventy-one patients received chemotherapy, 37rnpatients (52.11%) received a palliative intent, 18 patients (25.35%) got adjuvant intent, and 16rnpatients (22.4%) neoadjuvant intent. The median overall survival of osteosarcoma was 20.8 rn2.96 months (95% CI, 14-50-33.63) and 2-year overall survival was 45%.rnConclusion/recommendation: Most patients are delayed at presentation and have an advancedrndisease. Patients with osteosarcoma were under-investigated and received suboptimal care.rnPatients with osteosarcoma had low median and two-year overall survival. Overall survival wasrnfound to be significantly associated with curative surgery (p=0.001), distant metastasis atrnpresentation (p=0.004) and not taking chemotherapy (p=0.05) on bivariate Cox regression butrnthe intent of chemotherapy was the only significantly associated factor for overall survivalrn(p=0.005) on multivariate Cox regression.

Get Full Work

Report copyright infringement or plagiarism