Introduction: Central nervous system tumors are a heterogeneous group of neoplasms, theyrndiffer not only in their histomorphological features but also have a distinct biologicalrnbackground and disease course. CNS tumors are confined to the brain, spinal cord, meninges,rncranial and Para spinal nerves, with each tumor having its own features, location, morphology,rnprognosis and treatment.rnObjective:The purpose of this study is to provide the histopathological pattern of CNS tumors in arntertiary care center in Ethiopia.rnMaterial and method: A retrospective descriptive histopathological analysis of central nervous rnsystem tumors carried out in the Postgraduate Department of Pathology in Tikur Anbessa rnSpecialized Referral Hospital (TAH), Addis Ababa, Ethiopia. Patients data were retrieved fromrnthe archives of the department of Pathology for a period of 5 years from January 01, 2015 tornAugust 31, 2019.rnResult:A total of 565 cases were analyzed and a wide range of histopathological diagnosis ofrnCNS tumors was observed. Patients ages ranged from 2minths-80 years with a mean age of 36.9rnyears and a male to female ratio of 1:1.11. Majority of tumors had intracranial locationrn(499rncases, 88.3%).Most of CNS tumors were low grade belonged to Grade I 70% followed by gradernII 14. 8%. Tumors of meningeal tissue were most common 51.9% followed by neuroepithelialrn24.2 %. When examining the data pertaining to specific types of tumors, most frequent type ofrnCNS tumors was meningioma(272 cases, 48.1%) followed by astrocytoma (86 cases, 15.2%)rn.rnConclusion:The present study thus reflects the histopathological patterns of CNS tumors from ourrncenter. Although there is availability of advanced imaging techniques at present, stillrnhistopathological examination is gold standard in their diagnosis.The conventional H & Ernstaining is the mainstay for pathologic diagnosis, and IHC also plays a major role in differential rndiagnosis and improving diagnostic accuracy.