Introduction: Salivary gland tumors account for < 1% of all tumors and about 4% of allrnepithelial neoplasms in head and neck region, and can display a remarkable range ofrnmorphological diversity between different tumor types. The objectives of this study were tornanalyze, compare and contrast the demographic and morphological data of neoplastic and nonneoplasticrnsalivaryrnglandrnlesionsrnseenrnatrnTikurrnAnbessarnHospital,rnPathologyrndepartment.rnrnMaterials and Method: This was a descriptive, retrospective study of the salivary gland lesionsrndiagnosed from July 2015 up to June 2020 from the Tikur Anbessa Hospital, Department ofrnPathology archive. These were analyzed for age, gender, anatomical location of the tumors andrnmorphological typing. The salivary gland tumors were classified according to the 2017 WHOrnclassification system. rnResults: From a total of 378 cases reviewed, 339 files had complete medical records fulfillingrnthe study criteria. Of the 339 cases, 180 (53.1%) of the study subjects were females with an F: Mrnratio of 1.13:1. The commonest age group for both neoplastic and non-neoplastic salivary glandrnlesions was in the 3rnrdrn and 4rnthrn decades but spans a broad age range (2rnndrn to 6rnthrn decades of life). 143rn(42.2%) of the cases were non-neoplastic while the remaining 185 (54.6%) cases werernneoplastic. Eleven (3.2%) cases were diagnosed as normal glands. Majority of the salivary glandrnneoplasms were benign tumors, accounting for 111 (60%). rnAmong from the 143 non-neoplastic 76 (53.1%) were sialadenitis. More than half of thernsialadenitis, 47 cases (61.8%) were constituted by chronic non-specific sialadenitis followed byrnobstructive sialadenitis with sialolithiasis and lymphoepithelial sialadenitis, 7 cases (9.2%) each.rnThe most frequently affected anatomic location was the submandibular glands (62%) followedrnby the parotids (23.4%). rnOut of the 111benign tumors, PA was the most frequently occurring benign neoplasm with 99rncases (89.2%). The mean age of occurrence being 36.9 years and an F:M ratio of 1.4:1. Therncommonest site of occurrence was the parotids 36 (32.4%). The second most common benignrntumor were myoepithelioma and basal cell adenoma containing 3 cases (2.7%) each, both located rnin the major salivary glands, mainly the parotids and the submandibular glands. rnOf the malignant tumors, 40 (58.8%) were females and 30 (44.2%) were males with an F:M ratiornof 1.33:1. The mean age was 42.5 years. Mucoepidermoid carcinoma 23 (33.3%) cases was therncommonest salivary gland cancer followed by 21 cases of adenoid cystic carcinoma (30.4%), 6rncases of acinic cell carcinoma (8.8%) and 3 cases of adenocarcinoma, NOS (4.4%). 78 (42.4%)rncases occurred in the parotid, 40 (21.7%) cases arose from the palate and 25 (13.6%) of the casesrnoriginated from the submandibular glands. Four cases of lymphomas, 3 cases of primaryrnsquamous cell carcinomas and a single case of high grade sarcoma were reported. rnConclusion: Non-neoplastic lesions and tumors of the salivary glands show a slight geographicrnvariation. In our study, pleomorphic adenomas were the most frequent salivary gland tumorsrnsimilar to other African, Brazilian and Asian studies, but significant variation form studies donernin Croatia. Sialadenitis was the second commonest lesion obtained which was in agreement to most literatures in African and Caribbean nations. In our study, Warthin tumor was the fourthrnmost frequently identified benign salivary gland tumor which was in contradictory to most of thernliteratures.