Introduction: Globally, more than 20 million infants are born with Low Birth Weight and arnlarger proportion of these concentrating in Asia and Africa. Africa has a reported incidence ofrn14.3 %.Children born with low birth weight are more likely to die prematurely compared torninfants of normal birth weight. Likewise, these children experience more morbidity, both in thernshort and long term. Therefore, it is clear that low birth weight represents a heavy burden forrnhealthcare services worldwide.rnObjective: The aim of this study was to assess the prevalence and associated factors of low birthrnweight among newborn babies in Dessie town health institutions, Amhara region, Ethiopia.rnMethod: An institutional based cross sectional study design was conducted to assess thernprevalence and associated factors of low birth weight among newborn babies in Dessie townrnhealth institutions. The data was collected using a semi-structured pre-tested interviewer guidedrnquestionnaire. Data was cleaned manually, coded and entered into Epi -info version 7 andrnanalysed by SPSS version 20 statistical software.Bivariate and multivariate logistic regressionrnanalyses were employed to identify associated factors for low birth weight.After bivariaternregression analysis, variables with P value less than 0.2 were included in multivariable logisticrnregression. Adjusted odd ratio along with 95% CI was calculated to see strength of associationrnand P