Background-The emergence of drug resistance tuberculosis, particularly MDR-TB has become arnmajor public health problem in a number of countries and an obstacle to the global TB controlrnefforts. Information on treatment outcomes among hospital patients with multi drug resistantrntuberculosis (MDR-TB) and tuberculosis were scare in Ethiopia.rnObjective:- The study was carried out the prevalence of MDR-TB an Treatment outcomernamong tuberculosis patients attending at St. Peter TB specialized Referral Hospital from Januaryrn1, 2011to end of December 2013.rnMethod:- The study design was descriptive retrospective cross-sectional study using data collectedrnfrom medical records, radiological reports, bacteriological reports and consultant reports of MDR TB onrn680MDR tuberculosis patients. Data has taken from January 2011 to end of December 2013 .Frequency,rnmedian and range were computed for descriptive analysis. Binary and multiple variety analysis wererncomputed for inferential analyze. The ethical approval was obtained from AAU Institutional ReviewrnBoard (IRB).Patient care records were kept confidential.rnResult: The median age was 29 years (inter-quartile range 24â€“ 37), with similar sex proportionsrn(53.5% female).The number of MDR TB patient vary with their residence .Most of the patientsrnwere from Addis Ababa, the capital city of Ethiopia 385 (56;4%) followed by Oromo regionrn144(21%).. MDR TB prevalence increase from time to time as the study showed that 22.9% inrn2011 to 48$ in 1013, There were strong association between the contracting co infection andrnMDRTB unsuccessful outcome.rnConclusion and recommendation: MDR TB prevalence increase from time to time. There werernstrong association between the contracting co infection and MDRTB unsuccessful treatmentrnoutcome. Therefore; use of rapid, sensitive and specific methods for detecting MDR-TB must bernrecommended to combat the problem of MDR-TB.rnKeyword- MDR-TB, Resistance TB, Anti- TB Regimen