Background: Cancer affects all human kind involving all age groups and gender. When therndisease occurs in children, parents are negatively influenced socially and psychologically leadingrnthem to the development of depression representing a group prone to high levels of depression.rnThe period following their childâ€™s diagnosis and the initiation of treatment may be stressful andrndisturbing leading them to depression.rnObjective: the aim of the study was to assess the prevalence of depression and its associatedrnfactors among parents of children diagnosed with cancer at Tikur Anbessa specialized Hospital.rnMethods: A mixed approach quantitative and qualitative cross-sectional study design wasrnemployed from April 1st to May 15th 2017. Systematic random sampling technique was usedrnevolving 275 study participants for the quantitative part and participants for the qualitative partrnwere included conveniently. Study subjects for the qualitative study were subjects who are notrninvolved in the quantitative study. Structured interviewer guided instrument was used to gatherrninformation from study subjects for the quantitative part and an in-depth interview guide wasrnused for the qualitative section. Descriptive statistics including, frequencies and proportions wasrnemployed to describe the sociodemographic characteristics Bivariate and multivariate analysisrnusing Odds ratio was utilized to evaluate association between dependent and independentrnvariables. P-value less than 0.05 was considered as level of significance for associations.rnResult: the prevalence of depression among parents of children diagnosed with cancer in thisrnstudy was borderline depression, 7.3 %, moderate depression 6.2%, severe depression, 6.5 % andrnextreme severe depression 3.3%. Four variables showed statically significant association withrnparental depression which include, single parents {AOR=6.2; 95% CI (2.66-14.52) } , incomerngreater than 4500 birr {AOR=0.34; 95% CI (0.02-0.87) }, no previous history of depressionrn{AOR=0.18; 95% CI (0.07-0.43) } } and support source from insurance company {AOR=12.89;rn95% CI (3.12-53.18) } are respectively.rnConclusion and recommendation: parents of children diagnosed with cancer are at a greaterrnrisk of development of depression due to the fact that the disease is life threatening. Factorsrnassociated to the development of parental depression involves being single parenting, income,rnpresence of history of depression and other support sources. Therefore, linking the parents to thernsupport groups, psychosocial support from health care providers, governmental and non-rngovernmental organizations collaboration help to alleviate the condition.rnKey words, Parental depression, cancer, parents