Introduction: Pain is an unpleasant and subjective experience that involves sensory, affective,rncognitive, social, and behavioral components. The WHO statistics indicated that approximately 2rnmillion people suffer from pain everyday worldwide. Pain is one of the most common symptoms inrnpatients with malignant tumor, substantially affecting patientsâ€™ quality of life. The diagnosis andrntreatment of cancer considered as a major life stress can cause or aggravate the related psychologicalrndistress. Some studies have indicated that anxiety was one of the common psychological distresses inrncancer patients(1, 2).rnObjective: To assess the prevalence of cancer pain and anxiety and associated factors among patientsrnadmitted to oncology ward, TASH, Ethiopia, 2017.rnMethods: A cross-sectional study design was conducted. The sample size was calculated using singlernpopulation proportion formula. Data collectors were instructed to check the completeness of therninstrument just after its completion. Moreover, the collected data was coded, cleaned and exploredrnbefore analysis to check missing items and completeness of the collected data. Odds ratio was computedrnto assess the presence and magnitude of association between dependent and independent variables.rnMoreover, a logistic regression was done to control the possible confounding effect so as to assess thernseparate effects of the variables.rnResult: From the total 220 subjects, 72.3% had cancer or treatment related pain. Of those who had pain,rn80% had moderate to very severe pain and 62.3% did believe that the cause of their pain was cancerrnlesion. Moreover, only 48.2% used pain management. Interference of ADL due to pain was mentionedrnby 61.5% respondents of the total 160 subjects who have pain. Colorectal cancer 49(22.3%) was thernmost prevalent cancer type followed by lung cancer 29(13.2%). About 70(31.8%) of participants were inrnclinical stage IV. On the other hand 101(45.9%) of the respondents have waited 0-3 months. the restrn68(30.9%) and 51 (23.2%) had length of stay of 4-6 and >6 months before beginning RX, respectively.rnPain and anxiety were significantly associated. Besides, length of stay, duration since they knew theirrnDX, cancer types and stage of the disease were important determinants of cancer pain and anxiety.rnConclusion: The investigation revealed that three fourth of cancer patients suffered from pain andrnanxiety was common among cancer pts.rnRecommendation: It would be better if TASH administrative bodies, researchers and nurses ofrnoncology ward consider pain and anxiety as priority problems to be managed accordingly