Background: Simulation is a teaching and learning strategy that is increasingly used inrnnursing education to prepare students for the clinical workplace. Simulation is defined asrnactivities that mimic the reality of a clinical environment and are designed to demonstraternprocedures, decision making and critical thinking through techniques such as role playingrnand the use of devices such as interactive videos or manikins.rnObjective: To assess knowledge and perception towards clinical simulation among nurserneducators working at teaching institution in Addis Ababa, Ethiopia.rnMethodology: An institution based cross sectional study was used in teaching institutionrnlocated in Addis Ababa, Ethiopia. The study generates quantitative and qualitative datarnwith different measurements. One hundred three nurse educators were selected from ninernhealth science teaching institution with simple random sampling. Data was analyzed usingrnSPSS version 20. Logistic regression was done to identify association between therndependent and independent variables. The qualitative data was gathered through a keyrninformant interview and a focused group discussion.rnResults: Among the nurse educators 59.6% were found knowledgeable about clinicalrnsimulation. Of the respondents 74.4% of them found to have a positive perception aboutrnclinical simulation. A statistically significant association was found between educatorâ€™srnqualification and knowledge toward clinical simulation. The key-informant interview andrnFGD revealed that principal persons and students believe clinical simulation is veryrnimportant teaching methodology but there are a lot of challenges to apply it, lack ofrnmaterial and skilled personnel being the main challenge.rnConclusion and Recommendation: Majority of the respondent were found to bernknowledgeable about clinical simulation. Most of the respondent also found to have arnpositive perception toward clinical simulation. Teaching institution should give emphasisrnto advance knowledge of academic staff toward clinical simulation. Responsiblerngovernment bodies and teaching institutions needs to make the clinical skill rooms wellrnequipped with a skilled man power and required materials.rnKey words: Clinical simulation, Nurse Educators, Knowledge, Perception