Background: Clinical practice experiences are critically important to achieve the maximumrnlevel of clinical competence after receiving adequate theoretical and practical instructions.rnHowever graduates have problems in doing some easy duties .Most new bachelor graduates havernadequate theoretical knowledge but lack competence in the clinical environment.rnThe objective of this study was to assess factors affecting clinical practice competence ofrnundergraduate health science student in Hawassa University, medical and health SciencernCollege.rnMethods: Institutional based Cross-sectional study was carried among 345 Bsc nursing,rnmidwifery and health officer student and FGDs were carried among four groups. Simple randomrnsampling was applied to select study subject. Descriptive analysis was employed to describe thernpercentages and number distributions of the respondents for socio-demographic characteristics.rnBivariate analysis was used to see the association of independent with the dependent variable.rnCrude and adjusted odds ratios together with the corresponding 95% confidence intervalsrncomputed. A P-value ≤ 0.05 considered statistically significant in this study. Data was collectedrnby using a self-administered questionnaire for quantitative and unstructured questioner forrnfocused group discussions. Both quantitative and qualitative methods were triangulated and Datarnwas collected from April, 2015 to July, 2015.rnRESULT: In this survey the prevalence of clinical practice competency was found to be25.2%.rnIn this study, student with clinical instructor support had more ability to clinical practicerncompetency by 2 times (AOR=2.064, 95%CI 1.042, 3.694) than students who hadn’t got clinicalrninstructor support during clinical practice and students with clinical practice assessment checklistrnmore likely ability to clinical practice competency by 4 times (AOR=4.058, 95% CI 1.238,rn12.65) than students who hadn’t got clinical assessment checklist during clinical practice.rnCONCLUSION AND RECOMMENDATIONS: Clinical practice competency was 25.2%rnamong students who have clinical instructor support, conduciveness of clinical placement;rnclinical assessment checklist as well integrated learning methods.rnSo improving supervision of clinical instructor and designing appropriate clinical practicernprotocol has important to enhance clinical practice competency of student in Hawassa medicalrnand health Science College