Background: Hepatitis B is the most common serious liver infection in the world. Hepatitis Brninfection is caused by the hepatitis B virus which attacks the liver and can cause both acute andrnchronic disease and puts people at high risk of death from cirrhosis and liver cancer. HepatitisrnB infection is one of the major public health problems and is the tenth leading cause of death.rnObjectives: The aim of this study was to assess knowledge, attitude, practice and associatedrnfactors towards hepatitis B prevention among patients coming to public hospitals in AddisrnAbaba, Ethiopia, 2017.rnMethod: Health Institution based, cross-sectional study design was conducted from March tornApril 2017. A total of 422 patients were selected by random sampling method from publicrnhospitals in Addis Ababa, Ethiopia. Data was collected based on interview administered prerntested structured questionner. Descriptive analysis was done and level of knowledge, attitudernand practice was determined based on the mean value of questions asked and bivariate andrnmultivariate regression for analysis of relation between dependent and independent variables.rnThe data was checked for its completeness manually and then entered in EPI DATA versionrn3.1.1 and analyzed using SPSS version 22 statistical software package. Confidence intervalrn95% and P-Value < 0.05rnResult: From the total of 422 study participant the response rate was 396 (94%). Almost halfrnof the respondents had a poor knowledge 197(49.7), negative attitude of 190(48%) and poorrnpractice 266(67.2%). unemployment [AOR=0.236, [0.075,0.756] and housewife [AOR=0.284,rn[0.102,0.794] less likely associated with good knowledge, Monthly income [AOR=2.123,rn[1.022, 4.409] more likely and educational level less likely [AOR=0.235, [0.068, 0.812] withrnpositive attitude and marital status more likely (AOR= 3.409, 95% CI [1.380,8.422] with goodrnpractice.rnConclusion: Results from this study showed that poor knowlegdge, Negative attitude and poorrnpractice of patients towards HB. nearly half of the respondents had poor knowledge and morernthan half are with poor practice. Therefore, extensive health educational campaign should bernprovided to general population and especially to patients coming to public hospitals.rnKey Words: Knowledge, Attitude, Practice, Hepatitis B, Patients, Prevention, Addis Ababa