Background: Pain is a significant global problem in the field of health. Hospitalized neonatesrnexperience moderate to severe acute or chronic pain which minimizes their comfort and sufferingrnthat result in short and long term complications. Health care providers in developing countriesrnlack knowledge about neonatal pain management. Appropriate management of neonatal painrnprevents unnecessary hospital stay and suffering them from pain.rnObjective: The aim of the study was to assess the neonatal ICU nurses’ knowledge and practicernand factors associated regarding neonatal pain management at public hospital of Addis Ababa,rnEthiopia, 2020.rnMethods: Institutional based cross-sectional study design was used to collect data from fourrnselected public hospitals in Addis Ababa, from 22April-22May 2020. Simple random samplingrnwas used to recruit study participants using structured, self-administered questionnaire. Logisticrnregression model was used to identify the association. Odds ratio was used to test the strength ofrnthe associations between outcome and predictor variables at a 95% confidence level and p valuernof