Treatment Outcome And Associated Factors Of Neonatal Sepsis Among Neonates Admitted To Neonatal Intensive Care Unit In Public Hospitals Addis Ababa Ethiopia 2021.

Background: Neonatal sepsis is the major cause of neonatal mortality and morbidity globally,rnparticularly in developing countries. Despite studies revealed the extent of neonatal sepsis inrndeveloping countries, the findings were inconclusive. Identification of the determinants forrnneonatal sepsis and treatment outcome of newborns with sepsis is not adequate in Ethiopia. rnObjective: the aim of this study was to assess the treatment outcome of neonatal sepsis and itsrnidentifying factors among neonates admitted to neonatal Intensive care unit in public hospitals,rnAddis Ababa, Ethiopia, 2021.rnMethods- Institution based cross sectional study was conducted among 308 neonates admittedrnwith neonatal intensive care unit of selected public hospitals in Addis Ababa, Ethiopia. Afterrncoding, and entering the data to the software descriptive statistics such as proportion,rnfrequencies, cross-tabulation, and measure of central tendency were calculated. Hospitals andrnstudy participants were selected by lottery method and systematic random sampling techniquesrnrespectively. Data were collected using structured pretested questionnaire through face to facerninterview and by reviewing both maternal and newborns profile card. The collected data wasrnentered by using Epi-data version 4.6 and exported to SPSS version 26 for analysis. Variablesrnthat have p-value ≤ 0.25 were taken into the multivariable model to control for confounder.rnStatistical significance was declared at p-value ≤ 0.05. Odds ratio with 95% CI is used torndetermine the direction and strength of association between dependent and independent variable.rnResults: Among the total study 308 neonates, 75(24.4%) were died. Regarding the treatmentrnoutcome of neonatal sepsis neonates 18hours (AOR=3.66, 95% CI: (1.2011.15),rnrnHypertensive PIH/ Eclampsia (AOR=3.54, 95% CI: 1.24-10.09), Meropenumrn(AOR=4.16, 95% CI: 1.22-14.21) and CRP positive result (AOR=5.87, 95% CI: 1.53-22.56)rnwere significantly associated with poor treatment outcome of neonatal sepsis. rnConclusion and recommendation: The treatment outcomes of neonates 75.6% were recoveredrnand 24.4% were died. Empirical treatment was the pillar for management of neonatal sepsis inrnthis setup. There is a need health policy maker to focus on the prevention of risk factors ratherrnthan treating the underline disease.

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