Magnitude And Outcome Of Hepatoblastoma In Pediatrics Age Group In Tikur Anbessa Hospital Addis Ababa Ethiopia.

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Background: Hepatoblatsoma is the most common primary malignant liver tumor in pediatricsrnmost often occurs within the first 3 years of age. Most common clinical presentation isrnabdominal distension or abdominal mass. It is more common in south East Asia and Africa.rnThere are multiple associated factors which determine the magnitude and prognosis factor ofrnhepatoblatsoma. Indeed, Knowledge about the magnitude and outcome of hepatoblatsoma willrnhelp in designing prevention and early management intervention, thereby reducing the severityrnof the illness and Death of patients. rnMethods: A cross-sectional analytical study was done by collecting retrospective data fromrnpatient charts of patient evaluated at pediatrics hemato-oncology unit at TikurAnbesaarnSpecialized Hospital (TASH) in Addis Ababa, Ethiopia, during the period June 2010 to Julyrn2021GC. All patients whose records meet the inclusion were reviewed. Data cleaning andrnanalysis was conducted by the principal investigator. The data was summarized using frequencyrndistributions and summary tables and figures. The data was further analyzed using descriptivernstatistics and survival analysis by applying Kaplan Meier statistics. Conclusions of the studyrnwere drawn based on the analyses results. rnResult: A total of 25 patients fulfill the inclusion criteria were enrolled almost three forth of thernstudy participant were under 2 years, around 52% were females, majority of them were deliveredrnat term (72%) and had normal birth weight (64%).Most of the patient came from rural arearn(64%).All patients had abdominal ultrasound and abdominal-pelvic CT scan which is suggestivernof HB and around 64% of the mass involve both lobe of the liver. rnMajor clinical manifestations like abdominal mass and abdominal pain were present on allrnpatients followed by weight loss (80%) and anorexia (64%). Most of the patient had elevatedrnAFP >1000ng/ml (80%) and thrombocytosis (56%). 64% of the patients had PRETEXT stage 3rnHB. rnMagnitude of hepatoblatsoma in the last 10 years in tikuranbesa specialized hospital werern(25,2%) when we compared it with total solid tumors seen in the past 10 years . rnMost of the patient started chemotherapy (21, 84%) ,Cisplatin based regimen was mostrncommonly used regimen. Surgery was done only for 20% of the patient. Almost all post-surgicalrnpatients got improved. rnThe correlation function of tumor size decrement after treatment with serum AFP after treatmentrnand cycle of chemotherapy had significant correlation with P –value of 0.000 and 0.034rnrespectively. rnConclusion: hepatoblatsoma is the most common liver tumor in less than 5 year since surgery isrnthe main stay of management most of our patients died within 6month to 1 year after hospitalrnstay even before surgery, almost all of the survived children undergone surgical excision.

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Magnitude And Outcome Of Hepatoblastoma In Pediatrics Age Group In Tikur Anbessa Hospital Addis Ababa Ethiopia.

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