Validation of the Amharic Version of the Brief Fatigue Inventory (BFI-Am) for the Assessment of Cancer Related Fatigue in Ethiopian Cancer Patients, Addis Ababa, EthiopiarnGirma TeklernAddis Ababa University, 2017rnCancer related fatigue (CRF) is one of the distressing symptoms of cancer patients associated with cancer and its treatment. Although CRF is highly prevalent and has profoundly negative effect on patientâ€˜s quality of life (QoL), it is under-assessed and often goes undertreated in most cancer patients with the major reason being lack of valid and reliable screening and assessment tools in the language the patients understand. This study aimed to evaluate the psychometric properties of the Amharic version of the Brief Fatigue Inventory (BFI-Am) for the assessment of CRF in Ethiopian cancer patients. A cross sectional study was conducted among 202 cancer patients who had experienced CRF from Tikur Anbessa Specialized Hospital (TASH). The BFI-Am was developed by using forwardâ€“backward translation approach. Cancer patients who met the inclusion criteria and willing to participate in the study completed the BFI-Am along with the European Organization for Research and Treatment of Cancer Quality of life-C30 (EORTC-QLQ 30). The psychometric properties of the BFI-Am were assessed in terms of acceptability, reliability, and validity. Multiple linear regressions were utilized to determine predictors of CRF and the impact of CRF on quality of life also assessed. BFI-Am had Cronbachâ€˜s alpha of 0.97. The results of the factor analysis suggested a 1-factor solution explaining 78.4% of the variance, supporting the hypothesis of unidimentionality of the BFI-Am. An expected inverse correlation between the BFI-Am and the global health status/QoL; EORTC-QLQ 30 was observed (r=-0.324, P=0.000). Known group validity analysis showed that the BFI-Am mean score significantly increased with increasing Eastern Cooperative Oncology Group values (ECOG-PS) (p