Crinum abyssinicum is a species of bulbous plant that belongs to the family Amaryllidaceae. It isrnbelieved that the plant is native to Ethiopia, and known by the local name yejibb shinkurt (inrnAmharic). This plant is traditionally used for treatment of wound. No scientific evidence whichrnsubstantiates its traditional claim is, however, available to date. The objective of this study isrntherefore to evaluate the wound healing activity of bulbs extracts of C. abyssinicum in mice. Micernwere used for acute toxicity, wound healing and anti-inflammatory studies. For wound healingrnstudy, the 80% methanol extract of C. abyssinicum bulbs were formulated for topical applicationrnby incorporating it in simple ointment base B.P. in a concentration of 5% (w/w) and 10% (w/w).rnThe simple ointment and nitrofurazone (0.2%) skin ointment were used as negative and positiverncontrols, respectively. Toxicity of the formulated ointments was studied by skin irritation test onrnSwiss albino mice. For anti-inflammatory study, carrageenan-induced hind paw edema model wasrnused to evaluate the anti-inflammatory effect of the extract at concentrations of 100, 200 and 400rnmg/kg. Mice treated with Indomethacin (10mg/kg) and 2% Tween 80 served as positive andrnnegative controls, respectively. The antimicrobial activity of the extract at concentrations of 50,rn100 and 200 mg/ml was studied using agar well diffusion assay. Level of wound contraction,rnperiod of epithelialization, skin breaking strength, edema and zone of inhibition were determined.rnThe ointment formulation of the extract was found to be non-irritant at 5% and 10% concentrations.rnTreatment of wound with ointment containing 5% (w/w) and 10% (w/w) of 80% methanol extractrnof the bulbs exhibited significant increase in wound contraction rate, shorter epithelialization timernand higher skin breaking strength in the excision and incision wound model used as compared torncontrol. The plant extract also showed dose-dependent significant reductions (p < 0.05) ofrninflammation compared to control. The wound healing potentials, anti-inflammatory andrnantimicrobial effect of the 80% methanol extracts of C. abyssinicum bulb observed in this study isrnconsistent with the traditional claim of this plant for wound healing activity, and hence it is rniiirn rnrecommended to perform fractionation of crude extract in order to identify which fraction/s of thernplant extract is/are responsible for wound healing.