Drug therapy in the elderly needs an emphasis on the age related changes in drug pharmacokineticsrnand pharmacodynamics profile. As the age increase, people usually have more health problemsrnthat lead to the use of more medications than younger people do. Identification and prevention ofrndrug related problems (DRPs) in geriatric outpatients will be an important step towards reducingrnhospital admissions. There are different studies regarding to DRPs in general population butrnstudies regarding DRPs in elderly patients are scarce specifically in MIIRH there is no previousrnstudies. This study aimed to assess DRPs among chronic elderly patients. A hospital based crosssectionalrnstudyrnwasrnconductedrnonrn236rnchronicrnelderrnpatientsrnwhornwerernonrnfollowrnup-carernatrnMIIRH.rnrnDatarncollectionrnwasrndonernrnthrough patient interview and medical charts review. Epi data versionrn4.2 and IBM SPSS version 23 were used for data entry and analysis respectively. Descriptivernstatistics, cross-tabulation, univariable and multivariable binary logistic regressions were used andrnP < 0.05 was used to declare association. More than two-thirds of patients had two or morerncomorbid disease. The most common diseases encountered were hypertension (72.0%) andrndiabetes mellitus (56.7%). In this study, 740 medications were used with the mean number of drugsrnper day was 3.14 Â± 1.658 per patient. ACEIs 121(50.8%), antidiabetic agents 94(39.5%) and CCBsrn75(31.5%) were commonly prescribed class of drugs. Forty nine percent of patients encounteredrnat least one DRP and 118 drug related problems were identified. The average number of drugrnrelated problems per patient was 0.5. Non-compliance (45.8%) %) and needs additional drugrntherapy (24.6%) were major DRPs identified. antidiabetic agents were the most frequent drug classrninvolved in DRPs. From 740 medications, 122(16.5%) drugs were from beers medication list,rnwhere (44.1%) of participants were exposed at least to one potentially inappropriate medications.rnTo conclude, there is high prevalence of DRPs and PIMs. Marital status, number of comorbidityrnand number of drug prescribed have significant association with the occurrence of DRPs.