Wound Healing And Anti-inflammatory Activities Of Leaf Gel Of Aloe Trigonantha L.c. Leach In Rats

Aloe trigonantha L.C. Leach, which locally called ‘Eret’ (Amharic), is among endemic Aloernspecies of Ethiopia. Traditionally its leaf is used for the treatment of different ailments includingrnwound and infectious as well as inflammatory diseases. However, there was no in vivo studiesrnwhich prove its claimed use for wound healing and anti-inflammatory activity. Therefore, thernpresent study was aimed at evaluating the in-vivo wound healing and anti-inflammatory effectsrnof the leaf gel of the plant in rats. The leaf gel powder of the plant was prepared after drying therngel in lyophilizer. It was studied for wound healing activity topically by incorporating in simplernointment base in concentration of 5% (w/w) and 10% (w/w). Excision and incision models werernused for wound healing activity in rats. Parameters including wound contraction and period ofrnepithelialization were studied in case of the excision wound model, while wound tensile strengthrnwas evaluated using incision wound model. Xylene induced ear edema model and cotton pelletrninduced granuloma model were used for anti-inflammatory study. The leaf gel powder of A.rntrigonantha was given orally at dose of 100, 200 and 400 mg/kg in both models of antiinflammatoryrnrnstudies. An anti-inflammatory effect was measured by reduction of ear edemarnweight and reduction of wet exudate and dry granuloma weight in both of xylene induced earrnedema and cotton pellet induced granuloma models respectively. Treatment of wound withrnointment containing 5% and 10% (w/w) of the gel exhibited significantly increased woundrncontraction rate, shorter epithelialization time, higher skin breaking strength (p < 0.05) comparedrnto control. A. trigonantha leaf gel powder also produced dose-dependent significant reductionsrn(p < 0.05) of inflammation compared to control in both models. Therefore, results of the currentrnstudy demonstrated that A. trigonantha is a potential wound-healing and anti-inflammatory agentrnin rat models of wound and inflammation which provides evidence for the traditional claim

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