Evaluation Of The Diuretic Activity Of The Aqueous And 80 Methanol Leaves Extracts Of Ficus Sur Forssk (moraceae) In Rats

Ficus sur Forssk (Moraceae), commonly known as cape fig, is traditionally used in treatment of manyrndiseases and ailments. Although investigations on different pharmacological activities of the plant havernbeen conducted, its folklore use for diuresis has not yet been studied. The current study, therefore,rnFicused on the diuretic activity of aqueous and 80% methanol leaves extracts of Ficus sur in rats. Ratsrnwere randomly assigned into eight groups each consisting of six rats for diuretic test. The negativerncontrol group was treated with distilled water (2 mL/100gm); whilst positive control group was treatedrnwith furosemide (10 mg/kg). The doses (100mg/kg, 200mg/kg, and 400mg/kg) of aqueous and 80%rnmethanol extracts were administered to rats in group III-VIII, and urine volume was recorded every hourrnuntil the end of the fifthrn rnhour, and cumulative urine volume of each rat was taken. Then, diuretic activity,rndiuretic index, saliuretic index, natriuretic index and carbonic anhydrase inhibition index wererncalculated to make comparison among the groups. As an electrolyte excretion of all doses of the extractsrnshowed significant natriuresis (p

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