Evaluation Of Anticonvulsant Activity Of Aqueous And 80 Methanol Extract Of Pterolobium Stellatum (forssk)in Swiss Albino Mice

Pterolobium stellatum is used for the treatment of various illnesses including tuberculosis,rnpneumonia,and epilepsy in Ethiopian traditional medicine. The present study was conducted tornevaluate anticonvulsant activity of aqueous and 80% methanol extract of Pterolobium stellatumrn(Forssk)in Swiss albino mice using pentylenetetrazole (PTZ) induced seizure test. In addition,rnanticonvulsant activity of the study plant was evaluated using maximal electric shock (MES)induced seizure tests. The effect of both aqueous and 80% methanol extract on motorrncoordination was evaluated using a rota rod test. The 80% methanol extract has shown a doserndependent increase in latency to onset of seizure against PTZ induced seizure tests. In addition,rnboth aqueous and 80% methanol extract have shown dose-dependent reduction in duration ofrnhind limb tonic extension against MES induced seizure test. Furthermore, the aqueous extract atrndose 400mg/kg and methanol extract at doses 200mg/kg and 400mg/kg possess a significantrnreduction in duration of myoclonic seizure in the PTZ test (P

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