Nephrotic syndrome is a glomerular disorder of childhood that is characterized by heavyrnproteinuria, hypoalbuminemia, hypercholesterolemia, and edema. Despite the availability ofrneffective treatments, severe complication and relapse proteinuria which needs a prolongedrncorticosteroid treatment is the characteristic of the disease. The aim of this study was to evaluaternthe treatment outcome of nephrotic syndrome in children. A retrospective cross-sectional studyrnwas conducted among children diagnosed with nephrotic syndrome from 2010 to 2017 in AyderrnComprehensive Specialized hospital and Mekelle General Hospital. The data was entered andrnanalyzed using SPSS version 22. Binary logistic regression statistical tests were performed. Pvaluern