Anticonvulsant Activity Of 80 Methanol Extract And Solvent Fractions Of Ajuga Integrifolia Buch.-ham (lamiaceae) Leaves In Mice

Ajuga integrifolia is one of the species in the genus Ajuga that is used in the Ethiopian traditionalrnmedicine for the treatment of different ailments, including epilepsy. Thus, this study was initiatedrnto evaluate the traditional anticonvulsant use of 80% methanol leaves extract and solvent fractionsrnof Ajuga integrifolia. Acute routine screening tests; the pentylenetetrazole (PTZ) and maximalrnelectroshock (MES) models were used. The rota rod test was further performed to evaluaternneurotoxic effect of the plant. Swiss albino mice of 6-8 weeks old were randomly assigned to fiverngroups (n=6/group). The test groups received 100, 200 and 400mg/kg oral dose of crude extractrnand solvent fractions for both PTZ and MES tests as well as 2.5, 5 and 10mg/kg i.p. dose for rotarnrod test. The positive control groups received valproate 200mg/kg oral for PTZ, phenytoinrn25mg/kg oral for MES, and diazepam 5mg/kg i.p for rota rod test. The negative control groupsrnreceived oral dose of 10 ml/kg of distilled water or 2% tween 80. The crude extract produced doserndependent and statistically significant anticonvulsant effect on both PTZ and MES inducedrnseizures. It was suggested by delayed latency (p

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