Evaluation Of The Antidepressant-like Activity Of Sennasingueana (del.) Lock (fabaceae) In Rodents.

Depression is a multifactorial, chronic, and life-threatening disease with high prevalence,rndisability, and societal cost. Currently, 20%–30% of patients treated with commonly usedrnantidepressants do not achieve complete recovery and develop treatment-resistant depression.rnDrug resistance in addition to side effects and drug interactions are the major restrictions in therntreatment of depression. Thus, there is an urgent need to identify new treatment options includingrnherbal drugs. In this study, the essential oil extract of Senna singueana (Del.) (Fabaceae) wasrnassessed for its antidepressant property using the tail suspension test (TST) and the forcedrnswimming test (FST) models. To rule out the false-positive antidepressant-like activity of the oil,rnopen field test (OFT) was used. The composition of essential oil was determined using gasrnchromatography–mass spectrometry (GC/MS) analysis.rnAll animals were randomly assigned to six different groups for each model. Group I received thernvehicle (2% Tween 80) and served as a negative control. Group II received the standard drugrnimipramine (30 mg/kg) and served as a positive control. The test groups were from group III-VIrnand received increasing doses of the extract at 100 mg/kg, 200 mg/kg, 400 mg/kg, and 600mg/kg,rnrespectively. In TST, 600 mg/kg showed a significant immobility time reduction (56.6%) asrncompared to 100 mg/kg, 200 mg/kg (p

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