Validation of the Amharic Version of Multidimensional Fatigue Syndrome Inventory-Short Form for the Assessment of Cancer-Related Fatigue in Patients Receiving Treatment at Tikur Anbessa Specialized Hospital.rnDinksew TewuhibornAddis Ababa University, 2021rnIntroduction: Multidimensional fatigue syndrome inventory short form (MFSI-SF) is one of the instruments useful for measuring cancer-related fatigue (CRF). However, it was not validated in Ethiopia despite its established reliability and validity in other countries.rnObjective: The study was conducted to evaluate the validity and reliability of the Amharic version of MFSI-SF (MFSI-SF-Am) for assessing CRF in Ethiopian cancer patients.rnMethods: A hospital-based cross-sectional study was conducted from December 2020 to January, 2021 at the oncology center of Tikur Anbesa Specialized Hospital. Correlation analysis and independent samples t-test were employed to evaluate the construct and known group validity of the tool, respectively. Moreover, confirmatory Factor Analysis was used to assess factorial validity.rnResult: A total of 300 patients on cancer treatment were involved in the study. The Cronbachâ€™s alpha scores of MFSI-SF-Am subscales vary from 0.79 to 0.90 with overall score of 0.90. A moderate Pearson correlation of MFSI-SF-Am was observed with the Amharic version Brief Fatigue Inventory (BFI-Am) global score (r = 0.64) and the European Organization for Research and Treatment of Cancer Quality of LifernIIrnQuestionnaire-30 items (EORTC QLQ-C30) fatigue subscale (r = 0.66) suggesting good concurrent validity. MFSI-SF-Am scores were also sensitive to changes across the low and high groupings of Eastern Cooperative Oncology Group Performance Status (ECOG-PS), pain, depression and insomnia which approves a known group validity of MFSI-SF-Am.rnConclusion: The findings confirm the validity and reliability of the MFSI-SF-Am and that the tool can be valuable for CRF measurement in Ethiopian Amharic speaking patients.