Assessment on the implementation of Hospital Reform Guideline with reference tornPharmacy service in Addis AbabarnBethelehem GulelatrnAddis Ababa University, 2014rnThe Ethiopian hospital reform which is develop in 2010 is one of the importantrndocuments which established standardized, more patient oriented service inrnhospitals along with tools to monitor the performance. And one of the chapter in therndocument discussed minimum standards of hospital pharmaceutical service with itsrnindicators. This study was performed to assess the implementation of HospitalrnReform Guidelines in Addis Ababa with reference to Pharmacy service. The studyrnemployed a descriptive, cross sectional study design, using both quantitative andrnqualitative methods between August and November, 2013.As data collectionrntechnique the study used structured observation, in-depth interview and selfadministeredrnquestionnaire. The quantitative data was entered and analyzed by arnresearch data electronically capturing soft â€“ ware called RedCap. Whereas, thernqualitative data was analyzed thematically. Fifty percent of participating hospitalsrnhave quality offices over all do monitoring and evaluation. Most of this hospitalsrngoverned by FMOH. On the other hand, those hospitals under AACAHO do notrnhave such office (except one hospital). Although FMOH and AACAHO hospitalsrnfollow different implementation processes, there is no big difference regarding thernawareness level of pharmacy professionals. But there is a difference in the outcomernof hospital performance. The awareness of pharmacy professionals about EHRIGrnwas around 61% and the implementation of the 12 operational standards includedrnin pharmacy chapter of EHRIG was found to be in range 33% â€“ 83%. Regardingrnchallenge, all hospitals face problems associated with motivation, and commitmentrnof pharmacy professionals towards their job.rnKey words: Ethiopian Hospital Reform Implementation Guideline