Assessment of multi drug resistant tuberculosis rate and associated factors in public healthrnfacilities of Dessie City Administration, North East Amhara, Ethiopia.rnGashaw ShegawrnAddis Ababa University, 2015rnThe history of TB treatment has observed sequential development of resistance to anti-TBrndrugs. MDR-TB is defined as an MDR-TB suspect who is sputum culture positive andrnwhose TB is due to Mycobacterium TB that are resistant in-vitro to at least INH and RMP.rnThe emergence of MDR-TB is a threat for the populations of resource limited countries. InrnEthiopia MDR-TB is becoming a challenge, because of poor adherence to treatment,rnTB/HIV co-infection, a few diagnostic and treatment facilities and inadequate trained healthrnprofessionals. Dessie is densely populated town with high flow of people within the regionrnas well as from neighborhood regions. It is also vulnerable for counterfeit anti-TB drugsrnthrough contraband.rnThe aim of this study is to determine rate of MDR-TB and to identify associated factors inrnDessie City Administration, North East Amhara, Ethiopia.rnA facility based retrospective cross sectional study design employing medical recordsrnreview of TB registration books supplemented by key informantsâ€™ interviews which coverrnretrospective review period of July 1, 2012 to June 30, 2014.rnPrevalence rate of MDR-TB for combined, new and retreated TB cases of all form fromrnpublic health facilities, were found to be 2.1/100, 0.3/100 and 21.6/100 respectively.rnAdherence of TB patients to TB treatment (COR=9.0, 95% CI [1.03-78.57]) and previousrnhistory of TB treatment (AOR=66.87, 95% CI [6.94-644.10]) were found to be a risk factorsrnfor MDR-TB. And related to TB type all MDR-TB cases were dominantly pulmonary TB.rnKey words: Tuberculosis, Multi drug resistance, Rate, Associated factors, anti TB drugs.