Unintended pregnancy is common and abortion rates are rising worldwide in general in Africa inrnparticular and pose great challenge in achieving the MDGs. Safe abortion method especially MArnrelated awareness and practices of females are known to have crucial contribution in thernprevention and control of unsafe abortion and the resulting mortality and morbidity. The aim ofrnthis study was therefore to assess knowledge, attitude and practices regarding medicationrnabortion among regular undergraduate female students of the CSSs, AAU. A cross-sectionalrnquantitative study supplemented by key informantsâ€™ interview was conducted between 1st of Junernto 5th of July 2013. The quantitative data were collected using structured, self-administeredrnquestionnaire and the qualitative data were collected by the PI using interview guide. The age ofrnthe study participants ranged from 18 to 25 years with a mean age of 20.6 Â± 1.5. Three-fourth ofrnthe respondents (159,74.6%) knew what MA meant where 11 (6.9%) and 97(61%) of them hadrnhigh and low knowledge on MA respectively. Majority (142,66.7%) of the study participantsrnwould advise someone with unwanted pregnancy to undergo an abortion and 86 (40.4%) wouldrnconsider abortion if they had unplanned pregnancy. From 21 respondents who had abortionrnexperience, 13 (61.9%) used MA. The study revealed that majority of the female undergraduaternstudents in the CSSs has low knowledge regarding MA, though most of them have positivernattitude towards medication abortion. It would be much beneficial to female students ifrnmedication abortion awareness given by AAU in collaboration with DKT-Ethiopia, Ipas-rnEthiopia, AACARHB and local mass media.rnKey words: Abortion, Medication abortion, safe abortion, College of Social Sciences, AddisrnAbaba University, Undergraduate female Student