Antihypertensive Activity Of Aerial Parts Of Satureja Punctata (benth.) Briq. (lamiaceae)

Satureja punctata Benth. Briq. (Lamiaceae) locally known as ‘‘Lomishet’’ is among the plantsrnused in Ethiopian traditional medicine for the treatment of various diseases includingrnhypertension. The current study aimed at evaluating the antihypertensive activity of therndecoction of the aerial parts of this medicinal plant in guinea model of hypertension and itsrnvasorelaxant effect on isolated aorta. Acute hypertension was induced by surgical proceduresrninvolving clamping of the left renal artery and blood pressure was recorded invasively by directrncannulation method from the right common carotid artery. Intravenous administration of therndecoction at doses of 10, 20 and 30 mg/kg caused 13.66 ± 0.27, 34.35 ± 0.33, 45.78 ± 0.23%rn(n=6) fall in (p < 0.01) MABP, respectively, in normotensive guinea pig and a respective fall ofrn16.02 ± 0.28, 38.52 ± 0.50, 52.07 ± 0.42 % (n=6) (p < 0.01) MABP in renovascular hypertensivernguinea pig. The decoction also caused a dose-dependent relaxation of aorta precontracted withrnKCl at a concentration of 2.5- 40 mg/ml, with a maximum relaxation of 98.19 % achieved at 40rnmg/ml. Preparative reversed-phase HPLC analyses of the aerial part decoction of S. punctatarnresulted in isolation of two phenolic compounds, rosmarinic acid and linarin. The structures ofrnthese compounds were elucidated by utilization of spectroscopic techniques, i.e., MS, UV, IR,rn1D, and 2D NMR. Further, rosmarinic acid showed significant (p

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