In an attempt to integrate traditionally used herbal products into modern topical formulation,rnextracts of the leaves of Maesa lanceolata (Myrsinaceae), Osyris quadripartita Decn.rn(Santalaceae), Steganotaenia araliacea Hochst ExA. Rich (Apiaceae), Cadaba farinosarn(Capparidaceae) and; the aerial parts of Plantago lanceolata (Plantagonaceae) and Alachemillarnpedata A. Rich (Rasaceae) have been screened for their antibacterial and antifungal activities.rnAll hydroalcoholic extracts, except C. farinosa and S. araliacea were active against E. coli. And,rnall extracts had activities against S. aureus and P. aeroginosa. Similarly, screeneing of the totalrnextracts against Candida albicans and Trichophyton mentagrophytes indicated that all extracts,rnexcept P. lanceolata on both strains and C. farinosa on T. mentagrophytes, were active. But nonernof the extracts tested displayed activity against Aspergillus niger.rnThe antimicrobial activities of A. pedata and M. lanceolata were higher than those plants testedrnand hence, further works have been undertaken on these plants. In an attempt to localize thernactive ingredients, successive fractionation with petroleum ether, chloroform, acetone andrnmethanol have been carried out. The antimicrobial activity study of the various fractions revealedrnthat the antimicrobial effect of A. pedata was because of the non-polar components (petroleumrnether fraction) and that of M. lanceolata, the activities were distributed among the variousrnfractions. The action against T. mentagrophytes of the latter was entirely because of the polarrncompounds present in the methanol extract.rnTo assess the clinical utility of these plants, MICs were determined. Accordingly, the results forrnA. pedata were 5 mg/ml against S. aureus and E. coli and, 10 mg/ml for C. albicans using agarwellrndiffusion technique. The MIC of this plant extract using agar dilution technique on the samernbacteria was 0.125 mg/ml. Similarly; the MIC of M. lanceolata was 1.25 mg/ml against thernabovementioned bacteria and, 0.625 mg/ml against fungi using agar-well diffusion technique.rnAnd, using dilution technique, the result was 1.25 mg/ml for bacteria and 0.0625 mg/ml for fungi.rnAnti-inflammatory activities and semi-quantitative standardization works were also conductedrnand it was found that M. lanceolata has significant anti-inflammatory activity at 100 mg/kg andrn750mg/kg with better activity at 100 mg/kg. Similarly, A. pedata has also displayed antiinflammatoryrnactivity, even though the effect was less than M. lanceolata. The water extractivernvalues were 4.66 and 5.24% (W/W) for A. pedata and M. lanceolata, respectively. Successivernextractive values using petroleum ether, chloroform, acetone, methanol and water were (3.20,rn4.56), (3.38, 4.36), 1.28, 0.56), (5.38, 6.52), (4.60, 6.64) for A. pedata and M. lanceolata,rnrespectively. Ash value determination and TLC-fingerprinting were also conducted as part of thernstandardization work.rnOintments and creams were formulated using the hadroalcoholic extracts of A. pedata and M.rnlanceolata. Study on the in vitro performances of the proposed formulations indicated thatrnreleases from hydrophilic bases were better and polyethylene glycol-based preparations werernsuperior in activity than formulations prepared with hydrophobic bases. Furthermore, the in vitrornperformances of the formulated topical dosage forms were comparable to the activity of locallyrnavailable marketed antimicrobial products.