Evaluation Of The Analgesic And Anti-inflammatory Activities Of 80 Methanol Extract Of Leonotis Ocymifolia (burm.f.) Leaves

Pain and inflammation are the most common health problems treated with traditional remedies which mainly comprise medicinal plants. Leonotis ocymifolia is one of the medicinal plants used in folkloric medicine of Ethiopia for years to treat various pain and inflammation disorders. However, the plant has not been scientifically evaluated for the claimed activities.rnThe aim of the present study was to evaluate the anti-inflammatory and analgesic activities of the 80% methanol extract of Leonotis ocymifolia leaves using rodent models. The central and peripheral analgesic activity of the extract was evaluated by using Eddy‘s hot plate method and acetic acid-induced writhing, respectively. The anti-inflammatory activity of the extract was evaluated by using carrageenan-induced paw edema and cotton pellet granuloma method. The study was carried out in three different dose levels of extracts 100,200 and 400mg/kg orally. The extract did not produce any mortality up to 2000mg/kg. In the hot plate method, the extract at all doses showed a significant (p

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