Prevalence Of Chemo-induced Nausea And Vomiting And Its Impact On Patients Quality Of Life At The Oncology Unit Of Tikur Anbessa Specialized Hospital Addis Ababa Ethiopia

Nausea and vomiting remain among the most distressing side effects of treatment with chemotherapy.rnChemotherapy induced emesis (CIE) can impair quality of life (QOL) and poor control of emesis canrninterrupt or force withdrawal from critical chemotherapy. The prevalence of chemo-induced nausea andrnvomiting (CINV), and its impact on patients’ QOL were not assessed in Ethiopia.The objective of thisrnstudy was to assess the prevalence of CINV, and its impact on patients’ QOL after highly or moderatelyrnemetogenic chemotherapy at the oncology unit of Tikur Anbessa Specialized Hospital (TASH).Arndescriptive prospective cross sectional study involving interview and case note review were conductedrnamong patients evaluated and treated at oncology unit of TASH. The incidence of CINV and its impact onrnthe patients’ daily life were evaluated using the self-assessment tools. Patients who agreed to participaternreceived a diary covering the day of chemotherapy administration (day 1) and the following 4 days (day 2rnthrough 5). Patients were instructed to use the diary every day to record each emetic episode and tornprovide daily nausea assessments using a 100-mm visual analog scale (VAS) to rate the severity of nausearnexperienced during the preceding 24 h. Bi variate and Multivariate logistic regression was used to identifyrndeterminants of CINV. Independent t- test was used for comparison of group means between highlyrnemetogenic chemotherapy (HEC) and moderately emetogenic chemotherapy (MEC). Differences in thernproportion of patients that reported no impact on daily life (NIDL) between MEC and HEC treatedrnpatients were analyzed using X 2 tests (Fisher’s exact test). A total of 220 patients were assessable (74rnHEC patients, 146 MEC patients). Emesis was reported by 64.1% of patients (37.3 % acute, 50 %rndelayed) and nausea by 76.8 % (50.5 % acute, 65.5 % delayed). HEC patients reported significantly lowerrnmean functional living index (FLIE) total score than MEC patients (89.7 v 102.4 respectively; P < .001).rnAmong all patients, the nausea score was significantly lower than the vomiting score (46.5 and 51.6,rnrespectively; p < .001).The prevalence of CINV at oncology unit of TASH was found to be high and itrnadversely affects patients’ QoL despite antiemetic therapy even after treatment with only moderatelyrnemetogenic chemotherapy regimens. On the basis of the FLIE results in this study, nausea had a strongerrnnegative impact on patients’ daily lives than vomiting.rnKey words:rnchemo-induced nausea and vomiting (CINV), highly emetogenic chemotherapy (HEC) , moderatelyrnemetogenic chemotherapy (MEC). impact on daily life (NIDL) , Functional living index (FLIE),

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