Solanum incanum Linnaeus or Sodom/bitter apple (English), Embouy(Amharic), Hiddi(Afan Oromo) is a perennial, wild shrub like herb that grows up to 1.8 m in height that belongs to Solanaceae family which grows in many regions of Africa. In Africa, including Ethiopia the herb is used as a folklore remedy for different ailment such as skin problem like wound and inflammations. However, to date, no scientific report could be found in the literature concerning the in-vivo wound healing and anti-inflammatory activity. The purpose of this study is therefore to evaluate in- vivo wound healing and anti-inflammatory activity of 80% methanol extract of S. incanum L. leaves in mice.rnExtracts were studied for wound healing activity topically by incorporating in simple ointment base B.P. in concentration of 5% (w/w) and 10% (w/w). The animals were randomly divided into four groups in wound healing models and five groups (each containing six mice) for anti-inflammatory activity test. Simple ointment base (negative control) and nitrofurazone 0.2%(w/w)ointment was used as standard for activity comparison. For the study of in- vivo anti-inflammatory activity, the 80% methanolic extract was dissolved in 2% Tween 80. Two models were used for wound healing activity in mice viz. excision and incision. Carrageenan induced hind paw edema model was used for anti-inflammatory study. Parameters such as wound contraction, and period of epithelialization were studied in case of the excision wound model, while incision wound model was evaluated by determining tensile strength. Leaves extract ofrnS. incanum was given orally at dose of 100, 200 and 400 mg/kg in carrageenan induced hind paw oedema model and oedema was evaluated by determining mean increase in paw volume and percentage edema inhibition. Indomethacin 10mg/kg was used as reference standard for the activity comparison.rnTreatment of wound with ointment containing 5%(w/w) and 10% (w/w) 80% methanol extract exhibited significant(p