Membranes Interactions Mediated By Stickers A Simulaion Study

In this work, we investigate Moleculare dynamics simulation of Adhesion bond betweenrnreceptors and ligands. We modeled the ligand-receptor pairs(Adhesion bond) as Brownianrnparticle in viscous medium. Using the Langevin equation and employing the fourthrnorder Runge kutta method the position of the ligand-receptor pair is determined. Basedrnon the position's of ligand-receptor pairs the energy landscape of adhesion bond is obtained.rnThe coupled processes (formation and breaking) of adhesion bonds are simulatedrnby the Gillespie algorithms. These ligand-receptor interactions are modeled in the coupledrnchemical reactions model where breaking and rebinding of the adhesion bonds arernstochastic. The Adhesion bond life time as the stochastic process that is rely on probabilityrnfor bond breaking and rebinding of di erent realizations of the SSA are used. Thernstochastic relation between Nt, rn and f with NbrnNtrnwas examine

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