Association Of Plasma Warfarin Level With Monitoring Parameters Among Patients Treated At Hematology Referral Clinic Tikur Anbessa Specialized Hospital

Warfarin monitoring poses challenge to the treatment of thromboembolic disordersrnbecause out-of-range INRs which is encountered as a result of changes in numerousrnfactors. The fluctuation of INR in some patients might be dangerous because of thernnarrow therapeutic index of warfarin. The objective of this study is to evaluate thernassociation of plasma warfarin level with warfarin the clinical monitoring parameter,rnINR and related parameters. Institution based cross-sectional prospective study wasrnconducted recruiting 57 eligible patients on warfarin treatment at hematology referralrnclinic of Tikur Anbessa Specialized Hospital. Clinical data was retrieved from patientrncards and plasma warfarin level were determined using High Pressure LiquidrnChromatography with Ultra Violet – Visible detector. The associations of plasmarnconcentration with INR and weekly dose were low (rho = 0.375 at p = 0.006 and r = 0.283rnat p = 0.04) respectively. There was also statistically significant difference in the meanrnplasma warfarin concentration of patients who took effect enhancing co-medication andrnthose who took non-effect changing co-medication (p

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