The measurement of thermal neutron cross sections gives basic information about therninternal structure of atomic nuclei and their structure. Measurement of Thermal Neutronrncross-section of Sb -121 has been performed at the Addis Ababa University Nuclearrnphysics Laboratory using the concept of neutron activation Analysis. Irradiations withoutrnCadinium cover were performed and the neutron transmission through the cover wasrncalculated. High resolution gamma ray spectrometry measurements was undertaken inrnorder to check the consistency of the results. The thermal neutron cross section measuredrnfor Sb-121 using slow neutrons is ( 5.450.23b). The results are discussed andrncompared with previous Measurement. In general there is good agreement between thernobserved and calculated value of thermal neutron capture cross section.rnKeywords: Neutron sources, Neutron interaction, Thermal neutron cross section, Slowing downrnof Neutron, Neutron Activation analysis, HPGe