Evaluation Of In Vivo Antihypertensive And Ex Vivo V Asodepressor Activities Of The Seed Extract Of Calpurnia Aurea (ait.) Benth.subsp. Aurea (fabaceae)

Being the most important modifiable risk factor for stroke, renal, vascular and heart diseases; hypertension is still one of the leading causes of disability, morbidity and mortality among the populace worldwide. Consequently, the continued search for alternative antihypertensive agents of natural origin, with fewer side effects but greater effectiveness, necessitated evaluation of Calpurnia aurea for possible antihypertensive potential. In this study, the antihypertensive property of hydro-alcoholic seed extract of Calpurnia aurea was assessed using in vivo and ex vivo techniques. The in vivo antihypertensive efficacy of the crude extracts was evaluated in normotensive and 2K1C rat model of hypertension. The crude extract caused a significant fall in systolic blood pressure (SBP), diastolic blood pressure (DBP)and mean arterial blood pressure (MABP) at the doses of 15, 30 and 45 mg/kg in normotensive anaesthetized rats (p < 0.05, p < 0.01, p< 0.001).The effect on DBP was greater than SBP. In the same manner with the normotensive study, the BP fell dose-dependently and significantly in renal hypertensive rats, induced by renal ischemia. The extract produced 15.4% (p< 0.05), 26.9% (p< 0.01), 33.2% (p

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