Introduction: Brucea antidysentrica locally known as â€œAbaloâ€ is traditionally used to treat conditions like scabies and external parasites, dysentery, gonorrhea, eczema, cancer, malaria, and trypanosomosis among others. The fruits and leaves of B. antidysentrica are also claimed to promote wound healing and anti-inflammatory activities. However, there is no scientific confirmation that substantiates the traditional claims. Objective: to evaluate the wound healing and anti-inflammatory activities of both fruits and leaves extracts of B. antidysentrica in mice model. Materials and methods: Mice were used for wound healing and anti-inflammatory studies, while rats were used for skin irritation test. For studying healing activity, 80% methanolic extracts of the leaves and fruits were formulated in strength of 2% and 4% and 1% and 2% as ointment base respectively for topical applications of excision and incision wound models. The negative controls were treated with simple ointment while positive controls with nitrofurazone (0.2%) skin ointment. Extract solutions of the leaves and fruits in 2% Tween 80 at a dose of 100 mg/kg, 200 mg/kg and 400 mg/Kg body weight were used for anti-inflammatory activity tests orally against the inflammation produced by carrageenan injection. Negative controls for anti-inflammatory test were treated with 2% Tween80 and the positive controls with Indomethacin 10mg/kg. Parameters, including rate of wound contraction, period of complete epithelialization, skin breaking strength and edema inhibition were evaluated.rnResults: On the last day of treatment, 80% methanol fruits and leaves extracts showed a significant wound healing activity in strengths of 2% compared with negative control as evidenced by an increase in % wound contraction (p < 0.01) and a decrease in epithelization period (p