The homegarden is a small-scale traditional agricultural ecosystem and has played anrnimportant role in conservation and sustainable utilization of plant biodiversity. Anrnethnobotanical study was conducted in Sinan district, East gojjam Zone of Amhara regionrnand investigated diversity of useful plants, their use category in the homegardens and thernassociated local management practices. A multistage sampling technique was employedrnto select three kebeles and 150 households. Ethnobotanic information were gathered byrnconducting observation, free-listing, group discussions, and semi-structured interview.rnShannon-Weiner diversity index and Soreson`s index of similarity were used in the datarnanlysis and computed by using Microsoft Excel 2007. A total of 125 plant species werernrecorded and these are distributed in 51 families. Asteraceae stood first containing 15 (12rn%) species, Fabaceae came in the second place with 11 (8. 8%) species, and Poaceae,rnRosaceae and Solanaceae each in the third with 8 (6.4 %) species. Rhamnus prinoidesrncame out as the dominant species being found in 76.67% HGs followed by Vernoniarnurticifolia 60.67% and Ensete ventricosum 57.33%. Diversity indices with the value ofrn(H'= 3.38) highest for Gedamawit followed by Sinan mariyam (H'= 2.80) and Danguliern(H'= 2.62). Evenness index with the value (E = 0.73) highest for Gedamawit followed byrnSinan mariyam (E =0.65) and Dangulie (E=0.63). There were about more than fifteenrnmajor use reports of plants in the study area. 60(48%) of plants that occurred in thernhomegardens with multiple uses took the top position followed by 45(36%) live fencernplants and 43(34.4%) fodder plants among others. Therefore, it can be concluded thatrnhomegardens in the study area contain different types of plants and significantlyrncontribute to the livelihood of the people.