The research was carried out in Nole Kaba District to study the floristic diversity, structure, composition of JorgornWato Forest (JWF) and ethnobotany of medicinal and wild edible plants used in selected areas of Nole KabarnDistrict. Floristic data were collected from a total of 73 plots applying standard plot sizes. The number ofrnindividuals, dbh (diameter at breast height), and height of woody species (dbh > 2.5 cm) were enumerated andrnmeasured in each plot; their cover abundance was estimated. Ethnobotanical data were documented through semistructuredrninterviews (371 general informants of whom 174 were females & (12 key informants), group discussions,rnfield observations, market surveys, and pairwise comparisons. Forest structural attributes were computed usingrndescriptive statistics; plant communities were classified using cluster analysis. Redundancy Analysis was employedrnto analyze relationship between species distribution and environmental factors. Shannon diversity indices werernemployed to estimate species diversity. ANOVA, Sorenson's similarity, and correlation analysis were computed tornanalyze mean differences, similarity and relationships in floristic data. Ethnobotanical data were analyzed usingrndescriptive statistics and quantitative indices such as Factor of Informant Consensus (Fic), Fidelity Level (FL),rnPairwise Ranking, Correlation, Sorenson Similarity, Use Value and Cultural Importance Index (CI). ANOVA wasrnemployed to test the variation in ethnobotanical knowledge among informants and Multiple Linear Regressionsrn(MLR) was employed to determine the strength of the influence of variables that contributed to the knowledgernvariation. The floristic study found a total of 237 species belonging to 192 genera and 82 families. The highestrnImportant Value Index was recorded for Pouteria adolfi-friederici, followed by Syzygium guineense subsp.rnafromontanum. Five plant community types were identified. Species diversity and evenness were 3.73 and 0.80,rnrespectively. Altitude and slope significantly influenced (p < 0.05) species distribution across plant communityrntypes. One hundred sixty two medicinal plants belonging to 135 genera and 65 families were found from thernethnomedicinal and ethnoveterinsary study. The highest proportion of medicinal plants were herbs (47.5%),rnfollowed by shrubs (27.8%). Ehretia cymosa (FL = 100%), Pentas schimperiana (FL = 100%) and Loxogrammernabyssinica (FL = 94%) were among the medicinal plants showing high informant consensus. Age, healingrnexperience, gender, and proximity to forest revealed significant variation and these together accounted for 34.7%rn(R2 = 0.347) of the total variation in ethnomedicinal knowledge among informants. The ethnobotanical study alsornfound 39 WEPs species belonging to 31 genera and 27 families that are consumed by the community. Nutritionalrnanalysis of selected wild edible fruits found rich nutritional composition in the fruits. Medicinal plants with highrninformant consensus and wild edible fruits (e.g. Carissa spinarum, Syzygium guineense subsp. afromontanum,rnXimenia americana) with rich nutritional composition are recommended for further development andrnconservation.