Iron sulfate has a diversified uses in agriculture, chemical industries and waste water treatment plants. Although Ethiopia has a huge deposits of iron ore. Therefore, this study investigates the potential of the country to produce iron sulfate from local iron ore and sulfuric acid.rnIron samples has been taken from two ores namely Horu Guduru and Melkasedi in Oromia regional state characterized, 77% and 66% weight based iron oxide composition obtained from Horu Guduru and Melkasedi respectively. The sample from high iron oxide composition ore, Horu Guduru was reacted with sulfuric acid and hydro chloric acid subsequently by varying three process variables: temperature, reaction time and particle size.rnFrom the analysis the optimum iron sulfate yield obtained is 97.75% at temperature of (75oC), reaction time 60 min and particle size 1.00(which is