Improving the quality of salt using physic-chemical treatment process is an important issuernfor industrial and health benefit of the society. This study was performed to purify andrncharacterize the brine lake salt of Afdera and Dobi. The salt samples were dried in an ovenrnand the moisture content was determined. The levels of metal and heavy metal impuritiesrnwere determined using FAAS after wet digestion using HNO3. The concentration of Cdrncontents were not detected; however, the mean concentrations of other dissolved metals inrnthe sample of Afdera in ppm were 296 for Ca, 818.9 for Mg, 0.1145 for Cu, 0.0144 for Pb,rn0.0175 for Zn, and 2.0554 for Fe. For salt sample from Dobi the metals concentrations inrnppm were 635.7 for Ca, 666.3 for Mg, 0.0472 for Cu, 0.0139 for Pb, 0.0139 for Zn, andrn2.6342 for Fe. The percentage contents of sample from Afdera were 96.6 for NaCl, 1.09 forrnLoss of mass, 1.05 for matter insoluble, 1.08 for SO4, 1.60 for alkalinity, 7.8 for pH.rnSimilarly,the contents of sample from Dobi were 91.21 for NaCl, 1.25 for Loss of mass, 1.75rnfor matter insoluble, 8.12 for SO4, 1.80 for alkalinity, and 7.9 for pH. The crude saltrnsamples were treated by using NaOH, Na2CO3, and BaCl2 to reduce Carn2+rn, Mgrn2+,rn and SO4rn2-rn. rnUsing CCD with face centered statistical experimental design, interaction effects of processrnvariable, optimum operating conditions and the optimum purity of salt that can be achievedrnat these condtions were determined. The selected operating conditions for salt sample ofrnAfdera were 38.23 rn0rnC of reaction temperature, 2.65g of NaOH, and 2.69g of Na2CO3, 0.235g rnof BaCl2 and 50.26min of reaction time, With an optimum salt purity of 99.63 %.Similarly,rnthe selected operating conditions for salt sample of Dobi were 25rn0rnC of temperature, 2.97g of rnNaOH, and 3g of Na2CO3, 5.29g of BaCl2 and 27.58min of reaction time with an optimumrnsalt purity of 99.68 %.The model adequacy was checked by analysis of variance.Based onrnthe analysis for salt sample of Afdera, the correlation coefficients, R-Squared (Rrn2rn),adjusted rnR-Squared and predicted R-Squared havea value of 0.9997 , 0.9966, and 0.8105rnrespectively. For salt sample of Dobi,R-Squared (Rrn2rn), adjusted R-Squared and predicted R-rnSquared have a value of 0.9997,0.9970 and 0.8047 respectively.After purification the NaClrncontent of salt of Afdera and Dobi were enhanced to 99.65% and 99.60% respectively.