The leather market demands quality and competitive cost for producers as well as users.rnLeather producers use effective substituent to make the process efficient in order tornreduce the waste load and improve the quality of the final product. Fatliquoring is arnfundamental stage during the production process of leather. The source of fatliquoringrncan be formulated from emulsification of raw materials such as vegetable or seed oils andrnfats, wax, fish oil and paraffin. These enable them to penetrate leather properly tornenhance the major characteristics of leather such as softness, pleasant feel and strength.rnThis study showed the process for synthesis of sulphated fatliquor from locally availablernraw material, neem seed oil (SNOSFL). The fatliquor production process involvesrnpreparation of seed, extraction of oil by solvent and mechanical screw press , purificationrnof oil, sulphation of the neem oil with conc.H2SO4, washing and neutralize with 10%rnNaCl and 30% NaOH solutions respectively. The major sulphation reaction processrnparameters used for fatliquor production were reaction temperature, amount ofrnconc.H2SO4, and reaction time. In the experimental analysis results, the optimalrnconditions that maximize the degree of sulphation were found to be reaction temperaturernat 23.98 rnï‚°rnC, amount of conc. H2SO4 at 16.76 Wt. % and reaction time 3.28 h that yield therndegree of sulphation was 5.37%. The physicochemical characterization, spectroscopicrnanalysis (FT-IR, GC-MS) of synthesized fatliquor and neem oil, and the organoleptic andrnphysical test for the applied fatliquor on leather were done. The overall results confirmrnthe sulphated group during sulphation process in SNOSFL and the synthesized productrnhas a potential for the application garment leather.