The production of ethanol from biomass results in the co-current production of acidic materialrnknown as distillery spent wash or vinasse. It is generated at a rate of 10 to 15 times greater thanrnthe ethanol itself, and is characterized by a high dissolved organic matter content. Anaerobicrndigestion is the most effective methods for the treatment of such type of wastewater. In this work,rna combined adsorptionâ€“anaerobic digestion treatment of distillery wastewater was studied in orderrnto develop an effective procedure for increasing the anaerobic biodegradability of vinasse to reducernits environmental impact. The adsorption stage with banana peel as a pretreatment was evaluatedrnfor removal of phenolic compound. The removal of phenolic compound with this biosorbent wasrncarried out using Box-Behnken experimental design taking 3 factors, adsorbent dose, contact time,rnand particle size. The maximum phenol removal recorded was 76.425% at the optimum conditionrn(adsorbent dose of 20 g/L, contact time of 129.98 min, and particle size of 0.53 mm). Removalsrnof 22% in chemical oxygen demand (COD) was obtained in this stage. Among the adsorptionrnisotherm models analyzed, the Langmuir model fitted best to the experimental data with maximumrnadsorption capacity of 4.12 mg/g, and also the adsorption mechanism follows pseudo-second orderrnmodel. The pretreated vinasse was undergone to an anaerobic digestion process in the second stagernunder mesophilic condition. After anaerobic digestion, a global removal of 84% in COD, and overrn95% in phenols content were obtained. It was shown that, a combination of treatment method (i.e.rnbanana peel biosorption and anaerobic digestion) is a promising option for simultaneous removalrnof phenol and COD from molasses vinasse under the stated conditions.