The research sought to investigate the factors affecting the effectiveness of monitoring andrnevaluation system for biomedical engineering projects at Tikur Anbessa Specialized Hospital.rnThe research implemented a descriptive research design in pinpointing the research problem.rnThe research targeted 32 employees of Tikur Anbessa Specialized Hospital that are directlyrninvolved in the biomedical engineering projects, in which the researcher conducted arnconsecutive sampling method. Due to the current pandemic most of the institution physiciansrnwere involved in providing health care services for Corona Virus (COVID-19) victims, inrnwhich the response rate was 68.75%, where most of the data collection was performed throughrnonline survey. The research utilized a questionnaire and interview to collect primary data. Therncollected data from the questionnaires were analyzed through SPSS statistical package versionrn26. The findings were analyzed using means, standard deviation, percentages and frequenciesrnthen presented in a table format, in which the interview questions were used to discuss thernfindings. The main findings of the research are; the stakeholder management and participation,rnas well as the biomedical engineers and radiology technologist, are not involved in the projectrnfrom planning to closure, there is no service agreement for most of the machines that have beenrninstalled, the institution doesnâ€™t have a higher involvement in the procurement procedure,rnskilled professionals are not properly chosen, team organization and teamwork are not properlyrnmanaged, communication plan being vague. The research suggests most of the knowledgernareas in the project management field investigated in regards to the factors influencing therneffectiveness of monitoring and evaluation in biomedical engineering projects.as well as thernreplicating this study in other public health institutions, to enable generalization.