Background: Measles is respiratory disease caused by measles virus and spread through dropletsrnof patients. Approximately 20 million people are affected by measles every year worldwide withrnthe highest numbers in Africa. According to World Health Organization’ report 14,100rnconfirmed cases have been reported from Ethiopia in 2014. According to national guideline onrnMeasles, approximately 15% of vaccinated children at nine months of age fail to seroconvert,rnand are thus not protected after vaccination. In February 2016, Telo district reported increasedrnnumber of persons with fever, and generalized maculopapular rash. We investigated to confirmrnthe outbreak, identify risk factors and implement control measures.rnMethods: We employed 1:2 unmatched case-control study designs. We collected data byrninterviewing using questionnaire. We interviewed parents behalf of patients & controls whosernage was not appropriate for enquiring. We used case definition as per stated in national Measlesrnguideline. We collected specimens and tested at regional laboratory. We analyzed the data usingrnEpi-Info & ArcGIS.rnResults: Three kebeles were affected. A total of 68 Measles cases, 30 (44%) male and 38 (56%)rnfemale identified. All patients were under 15 years and 58(85%) of them were under 5 years ofrnage. Attack Rate was 1.3%, of this 2.5% was among less than one year old, 27 (40%) of patientsrnwere not vaccinated with measles. A measles vaccination dropout rate in affected kebeles wasrnhigh (44, 13 & -23 of the three kebeles). Three Tested samples are all positive for measles (IgM).rnTravel history to affected areas (AOR 9.7; 95%CI: 1.7 – 55) and unvaccinated (AOR 4.4;rn95%CI: 1.6 – 11.6) were statistically significantly associated risk factors for the infection andrnage group greater than five years was protective factor(AOR=0.18, 95%CI: 0.05 – 0.66).rnConclusion: This investigation confirmed an outbreak of measles and unvaccinated againstrnmeasles and travel history to affected area were significant risk factors for contracting measles.rnWe recommended supplementary immunization and strengthening the routine vaccination.rnKeywords: Measles outbreak, Telo district, Kefa zone, Ethiopia