Evaluation Of Anti-malarial Activity Of 80 Methanol Extract And Solvent Fractions Of The Leaves Of Olea Europaea Linn (oleaceae) In Mice

Evaluation of the anti-malarial activity of 80% methanol extract and solventrnfractions of the leaves of Olea europaea (Oleaceae) in micernDesye MisganawrnAddis Ababa University, 2016rnDrug resistance posed a challenge to malaria control measures. This called forrndevelopment and discovery of new chemotherapeutic agents from alternative sources suchrnas medicinal plants. This study aimed to investigate antimalarial activity of Olearneuropaea, an extensively used plant in Ethiopian folklore medicine. The leaf was extractedrnby maceration using 80% methanol and the crude extract was then successivelyrnfractionated using solvents of differing polarity (chloroform, n-butanol and water). Antimalarialrnactivity of various doses of the extract and fractions (200, 400 and 600 mg/kg)rnwas evaluated using the 4-day suppressive test (both crude and fractions), as well asrnRane’s and prophylactic tests (crude extract only). The crude extract significantly reducedrnparasitemia (p

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