Background: Influenza and influenza-like-illness (ILI) is the most contagious respiratory diseases having substantial public health problem. It is associated with higher morbidity and mortality during outbreak, especially among the elderly and children. The aim of the study was to identify existence of outbreak, etiologic agent, magnitude, associated factors with ILI to contain the outbreak.rnMethods and materials: We conducted unmatched case-control study in Jawi district from 29 February through 10 March 2016 G.C. We enrolled 28 cases and 112 controls. We conducted face to face interview using structured questionnaire. Data were entered and analyzed using Epi-Info and SPSS. We performed binary logistic regression analysis to explore predictors of ILI.rnResults: From 29 February through 10 March 2016, we identified 28 cases (attack rate, 20.55/100,000) and no death. From total cases, 4(14.29%) confirmed and 8 (28.6%) admitted cases were reported. Female cases were 67.9%. Majority affected age groups were