Background: None of the contraceptive methods are fully side-effect free. The number onernreason women give for dissatisfaction with discontinuation hormonal contraception is side effects,rnsuch as mood disorder and depression that lead to discontinuation. The purpose of this tudy wasrnto assess the association between contraceptive use and depression among female employeesinrngovernmental institution in Sebeta town, Oromia regional state, central Ethiopia.rnMethods: Institutional based cross sectional study was conducted among female employees inrngovernmental institutions found in Sebeta town, conducted from August 2015 to Jun 2016. Selfadministeredrnquestionnaire was used to collect data. The data were obtained through a standardrnquestionnaire including PHQ-9 (Patient Health Questionnaire-9). The questionnaire was includedrnsocio demographic variable, social and economic factors, environmental variables. Data entryrnwas being done using EPI-info version 7 and analysis was done using SPSS for windows versionrn20. Associations between determinants and outcome of interest (depression) was analyzed usingrnmultiple logistic regression, and was displayed using odds ratio with confidence intervals.Logisticrnregressions were used to assess the impact of different determinants for depression.rnResults:According to the PHQ-9, 34.10% women employees were identified by PHQ-9 as havingrnhad any form of depression diagnosis disorder. After adjusting confounding effects current use ofrncontraceptive was not associated with depression, however marital status (AOR=2.31,95%CIrn(1.00, 5.33)), ever use of injectable(AOR=1.59,95%CI(1.02, 2.49)), Exposure of violencern(AOR=1.98,95%CI(1.20, 3.26)), sufficiency of income (AOR=2.11,95% CI (1.26, 3.53)), totalrnfamily size(AOR=1.50, 95%CI(1.02, 2.20)), problems of everyday living foodrncost(AOR=3.47,95%CI(1.56,7.67)) and problems of everyday living house furniture costrn(AOR=1.56,95% CI (1.01, 2.39)) were statistical significant.rnConclusion; In this study, there is no association between current use of contraception andrndepression. Marital status, ever use of injectable, exposure of violence, income covering livingrnexpenses, total family size, problems of everyday living food cost and problems of everydayrnliving house furniture cost were the determinants ofdepression; therefore, women should be awarernof using hormonal contraceptive with out fearing on its side effect related to depression.rnKey words: Contraceptive methods and Depression.