Prevalence Of Drug Resistance Of Mycobacterium Tuberculosis In Harar (eastern Ethiopia)

A hospital based cross sectional study was carriedrnout in order to describe the magnitude of antituberculosisrndrug resistance and identify the riskrnfactors associated with it.rnThe study was carried out in Harar tuberculosisrncentre which is the major tuberculosis treatment centrernin eastern Ethiopia. A total of 338 smear/culturernpositive patients were enrolled in the study betweenrnOctober 10, 1994 and January 20, 1995. Exposure statusrnwas determined through interview; drug resistance and HIVrnstatus were determined through laboratory investigation.rnThe overall prevalence of resistance to one or morernanti-tuberculosis drugs was 126/338 (37.3%). Initialrnresistance was 82/252 (32.5%) while that of acquired wasrn44/86 (51 . 2%). History of previous treatment was thernstrongest predictor of anti-tuberculosis drug resistancern(p

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